Copeptin – the Better Vasopressin (AVP/ADH)

Arginine vasopressin (AVP), also called antidiuretic hormone (ADH) is one of the key hormones in the human body. AVP has important physiological functions, including vascular tonus, the homeostasis of fluid balance and regulation of the endocrine stress response. Ref-1

Electrolyte / vasopressin-dependent disorders


Because of technical limitations of vasopressin assays, vasopressin (also known as antidiuretic hormone - ADH, arginine vasopressin, AVP) concentrations were rarely measured in the past. The vasopressin surrogate Copeptin now opens the possibility to take full advantage of the hormone’s diagnostic potential. Copeptin is routinely measured for differentiate all forms of diabetes insipidus from primary polydipsia with an easy to use assay technology at highest sensitivity and stability.

"Quantification of AVP can be difficult, but copeptin is stable in plasma and can be easily measured with a sandwich immunoassay. For this reason, copeptin has emerged as a promising marker for the diagnosis of AVP-dependent fluid disorders." Christ-Crain and Fenske, 2016. Nature Reviews

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Advantages of Copeptin measurement

Extremely high stability ex vivo

Ex vivo Copeptin stability (<20% loss of analyte) has been shown even for at least 7 days at room temperature. Ref-3

Not significantly bound to platelets

Results you can trust; AVP in contrast is bound to platelets leading to falsely elevated or varying measurements of free plasma AVP. Ref-3

Sensitive Automated sandwich-immunoassay

B·R·A·H·M·S Copeptin proAVP KRYPTOR is available on KRYPTOR Compact PLUS, a fully automated bench-top analyzer with easy and continuous sample loading backed by the Nobel Prize-winning TRACE technology. Ref-3

Correlates better with serum osmolality than Vasopressin itself

Copeptin helps to better evaluate response to osmotic and haemodynamic changes. Ref-4

Reduced physical and psychological stress for patients

The ease and speed of BRAHMS Copeptin proAVP KRYPTOR assay improves the diagnosis of AVP-dependent fluid disorders, for a better patients care. Ref-2Ref-5

Easy to measure

Available on a fully automated platform


Find out more on the vasopressin surrogate Copeptin


Get this book for free

The utility of copeptin in neuroendocrinological clinical practice

Authors: Dr. Fabio Settanni Bsc, PhD / Dr. Alessandro Berton, MD

Table of content:

  • Introduction: what is copeptin?
  • Copeptin and differential diagnosis of PPS
  • Copeptin and differential diagnosis of hyponatremia
  • Case studies
  • Principal analytes and reference ranges
  • List of Abbreviations/Acronyms

Available in the following languages:

  • EN: The utility of copeptin in neuroendocrinological clinical practice
  • DE: Der Nutzen von Copeptin in der neuroendokrinen klinischen Routine
  • ES: La utilidad de la copeptina en la práctica clínica de neuroendocrinología
  • FR: Utilité de la copeptine dans la pratique clinique en neuroendocrinologie
  • IT: Utilità della copeptina plasmatica nella pratica clinica della neuroendocrinologia

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Further links


Ref-1: Morgenthaler et al. Copeptin – Biochemistry and Clinical Diagnostics, UNI-MED – 2015

Ref-2: Fenske et al. JCEM 2011

Ref-3: Morgenthaler et al. Clin Chem 2006

Ref-4: Balanescu et al. JCEM 2011

Ref-5: Timper et al. JCEM 2015

Ref-6: Christ-Crain and Fenske. Nature Reviews Endocinology 2016

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