Copeptin: Overcome the Limitation of Vasopressin (AVP/ADH) Measurement

Arginine vasopressin (AVP), also called antidiuretic hormone (ADH) is one of the key hormones in the human body. AVP has important physiological functions, including vascular tonus, the homeostasis of fluid balance and regulation of the endocrine stress response.^Ref-1 But due to technical limitations of vasopressin assays, vasopressin concentrations were rarely measured in the past.

"Quantification of AVP can be difficult, but copeptin is stable in plasma and can be easily measured with a sandwich immunoassay. For this reason, copeptin has emerged as a promising marker for the diagnosis of AVP-dependent fluid disorders." Christ-Crain and Fenske. Nature Reviews Endocrinology 2016

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Advantages of Copeptin measurement

Extremely high stability ex vivo
Ex vivo Copeptin stability (<20% loss of analyte) has been shown even for at least 7 days at room temperature. ^Ref-2
Not significantly bound to platelets
Results you can trust; AVP in contrast is bound to platelets leading to falsely elevated or varying measurements of free plasma AVP.^Ref-2
Sensitive Automated sandwich-immunoassay
B·R·A·H·M·S Copeptin proAVP KRYPTOR is available on KRYPTOR Compact PLUS, a fully automated bench-top analyzer with easy and continuous sample loading backed by the Nobel Prize-winning TRACE technology.
Correlates better with serum osmolality than Vasopressin itself
Copeptin helps to better evaluate response to osmotic and haemodynamic changes.^Ref-3
Reduced physical and psychological stress for patients
The ease and speed of BRAHMS Copeptin proAVP KRYPTOR assay improves the diagnosis of AVP-dependent fluid disorders, for a better patients care.^{Ref-4, Ref-5, Ref-6}
Easy to measure
Available on a fully automated platform

Find out more on the vasopressin surrogate Copeptin

References

Ref-1: Morgenthaler et al. Copeptin – Biochemistry and Clinical Diagnostics, UNI-MED – 2015

Ref-2: Morgenthaler et al. Clin Chem 2006

Ref-3: Balanescu et al. JCEM 2011

Ref-4: Fenske et al. JCEM 2011

Ref-5: Timper et al. JCEM 2015

Ref-6: Christ-Crain and Fenske. Nature Reviews Endocrinology 2016