Copeptin: Overcome the Limitation of Vasopressin (AVP/ADH) Measurement

Arginine vasopressin (AVP), also called antidiuretic hormone (ADH) is one of the key hormones in the human body. AVP has important physiological functions, including vascular tonus, the homeostasis of fluid balance and regulation of the endocrine stress response.^Ref-1 But due to technical limitations of vasopressin assays, vasopressin concentrations were rarely measured in the past.

"Quantification of AVP can be difficult, but copeptin is stable in plasma and can be easily measured with a sandwich immunoassay. For this reason, copeptin has emerged as a promising marker for the diagnosis of AVP-dependent fluid disorders." Christ-Crain and Fenske. Nature Reviews Endocrinology 2016

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Advantages of Copeptin measurement

• Extremely high stability ex vivo
  Ex vivo Copeptin stability (<20% loss of analyte) has been shown even for at least 7 days at room temperature. ^Ref-2
• Not significantly bound to platelets
  Results you can trust; AVP in contrast is bound to platelets leading to falsely elevated or varying measurements of free plasma AVP. ^Ref-2
• Sensitive Automated sandwich-immunoassay
  B·R·A·H·M·S Copeptin proAVP KRYPTOR is available on B·R·A·H·M·S KRYPTOR compact PLUS, a fully automated bench-top analyzer with easy and continuous sample loading backed by the Nobel Prize-winning TRACE technology.
• Correlates better with serum osmolality than Vasopressin itself
  Copeptin helps to better evaluate response to osmotic and haemodynamic changes. ^Ref-3
• Reduced physical and psychological stress for patients
  The ease and speed of B·R·A·H·M·S Copeptin proAVP KRYPTOR assay improves the diagnosis of AVP-dependent fluid disorders, for a better patients care. ^{Ref-4, Ref-5, Ref-6}
• Easy to measure
  Available on a fully automated platform

Find out more on the vasopressin surrogate Copeptin

• Pathophysiology of vasopressin and Copeptin release >
• Electrolyte / vasopressin-dependent disorders >
• Download Product Specifications Thermo Scientific B·R·A·H·M·S Copeptin proAVP KRYPTOR >