Studies about Copeptin

A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus

The direct measurement of hypertonic saline–stimulated plasma copeptin had greater diagnostic accuracy than the water-deprivation test in patients with hypotonic polyuria.
https://www.nejm.org/doi/full/10.1056/NEJMoa1803760

Additional Info

  • Indication: Electrolyte Disorders
  • Authors: Wiebke Fenske, M.D., Ph.D., Julie Refardt, M.D., Irina Chifu, M.D., Ingeborg Schnyder, M.D., Bettina Winzeler, M.D., Juliana Drummond, M.D., Antônio Ribeiro-Oliveira, Jr., M.D., Ph.D., Tilman Drescher, M.D., Stefan Bilz, M.D., Deborah R. Vogt, Ph.D., Uwe Malzahn, Ph.D., Matthias Kroiss, M.D., Ph.D., Emanuel Christ, M.D., Ph.D., Christoph Henzen, M.D., Stefan Fischli, M.D., Anke Tönjes, M.D., Beat Mueller, M.D., Jochen Schopohl, M.D., Jörg Flitsch, M.D., Georg Brabant, M.D., Martin Fassnacht, M.D., and Mirjam Christ-Crain, M.D., Ph.D.
  • Source: N Engl J Med 2018; 379:428-439 DOI: 10.1056/NEJMoa1803760

Plasma copeptin and chronic kidney disease risk in 3 European cohorts from the general population

High copeptin levels are associated with the development and the progression of CKD in the general population. Intervention studies are needed to assess the potential beneficial effect on kidney health in the general population of reducing vasopressin secretion or action.
https://doi.org/10.1172/jci.insight.121479 >

Additional Info

  • Indication: Nephrology
  • Authors: Boustany R, Tasevska I, Meijer E, M. Kieneker L,Enhörning S, Lefèvre G, Mohammedi Kl,1, Marre M, Fumeron F, Balkau B, Bouby N, Bankir L, Bakker S, Roussel R, Melander O, Gansevoort RT and Velho G
  • Source: JCI Insight. 2018;3(13):e121479.

Is serum copeptin a modifiable biomarker in autosomal dominant polycystic kidney disease?

Copeptin (the C-terminal glycoprotein of the precursor AVP peptide) is an accurate surrogate marker of AVP release that is stable and easily measured by immunoassay. Cohort studies show that serum copeptin is correlated with disease severity in ADPKD, and predicts future renal events [decline in renal function and increase in total kidney volume (TKV)].
https://www.ncbi.nlm.nih.gov/pubmed/29527508 >

Additional Info

  • Indication: Nephrology
  • Authors: Tasneem M, Mannix C, Wong A, Zhang J and Rangan G
  • Source: World J Nephrol 2018;7 (2),Mar 6: 51-57
  • Access: Open Access

Effect of Coaching to Increase Water Intake on Kidney Function Decline in Adults With Chronic Kidney Disease: The CKD WIT Randomized Clinical Trial

Among adults with chronic kidney disease, coaching to increase water intake compared with coaching to maintain the same water intake did not significantly slow the decline in kidney function after 1 year. However, the study may have been underpowered to detect a clinically important difference.
https://www.ncbi.nlm.nih.gov/pubmed/29801012 >

Additional Info

  • Indication: Nephrology
  • Authors: Clark WF, Sontrop JM, Huang SH, Gallo K, Moist L, House AA, Cuerden MS, Weir MA, Bagga A, Brimble S, Burke A, Muirhead N, Pandeya S and Garg AX
  • Source: JAMA 2018;319 (18),May 8: 1870-1879.

Copeptin as a Prognostic Marker in Acute Chest Pain and Suspected Acute Coronary Syndrome

Copeptin appears to be an independent predictor of long-term mortality in a selected population of patients suspected for an ACS.
https://www.ncbi.nlm.nih.gov/pubmed/29619130 >

Additional Info

  • Indication: Cardiology
  • Authors: Morawiec B, Kawecki D, Przywara-Chowaniec B, Opara M, Muzyk P, Ho L, Tat LC, Gabrysiak A, Muller O and Nowalany-Kozielska E
  • Source: Dis Markers 2018;2018 6597387.
  • Access: Open Access
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