Studies about Copeptin

Copeptin role in polyuria-polydipsia syndrome (PPS) differential diagnosis and reference range in paediatric age

Copeptin evaluation holds promises as a diagnostic tool in paediatric PPS; its interpretation might be useful to promptly distinguish NDI, even avoiding the WDT need.
https://www.ncbi.nlm.nih.gov/pubmed/29464737 >

Additional Info

  • Indication: Electrolyte Disorders
  • Authors: Tuli G, Tessaris D, Einaudi S, Matarazzo P and de Sanctis L
  • Source: Clin Endocrinol (Oxf). 2018 Jun;88(6):873-879.

Copeptin levels and commonly used laboratory parameters in hospitalised patients with severe hypernatraemia - the "Co-MED study"

Copeptin and urea reliably identify patients with CDI and are therefore helpful tools for therapeutic management in patients with severe hypernatraemia.
https://www.ncbi.nlm.nih.gov/pubmed/29422070 >

Additional Info

  • Indication: Electrolyte Disorders
  • Authors: Nigro N, Winzeler B, Suter-Widmer I, Schuetz P, Arici B, Bally M, Refardt J, Betz M, Gashi G, Urwyler SA, Burget L, Blum CA, Bock A, Huber A, Muller B and Christ-Crain M
  • Source: Crit Care 2018;22 (1),Feb 9: 33.
  • Access: Open Access

Primary polydipsia in the medical and psychiatric patient: characteristics, complications and therapy

The gold standard when differentiating between these disorders has been the water deprivation test. However, new options for distinguishing between these entities have been proposed e.g., measurement of copeptin, a reliable surrogate marker of the hormone arginine vasopressin (AVP).
https://www.ncbi.nlm.nih.gov/pubmed/29120013 >

Additional Info

  • Indication: Electrolyte Disorders
  • Authors: Sailer C, Winzeler B and Christ-Crain M
  • Source: Swiss Med Wkly 2017;147 Nov 9: w14514.
  • Access: Open Access

Effects of hydration on plasma copeptin, glycemia and gluco-regulatory hormones: a water intervention in humans

Both acute and 1 week extra water intake potently reduced copeptin concentration. In those with the greatest decline (water-responders), who are typically low drinkers with high baseline copeptin, water induced a reduction in fasting glucagon. Long-term trials assessing the effect of water on glucometabolic traits should focus on low-water drinkers with high copeptin concentration.
https://www.ncbi.nlm.nih.gov/pubmed/29242971 >

Additional Info

  • Indication: Electrolyte Disorders
  • Authors: Enhorning S, Tasevska I, Roussel R, Bouby N, Persson M, Burri P, Bankir L and Melander O
  • Source: Eur J Nutr 2017;Dec 14: (Diabetes mellitus)

Release and Decay Kinetics of Copeptin vs AVP in Response to Osmotic Alterations in Healthy Volunteers

Copeptin is released in equimolar amounts with AVP in response to osmotic stimulation, suggesting its high potential as an AVP surrogate for differentiation of osmotic disorders. Furthermore, we here describe the decay kinetics of copeptin in response to osmotic depression enabling to identify a half-life for copeptin in direct comparison with AVP.
https://www.ncbi.nlm.nih.gov/pubmed/29267966 >

Additional Info

  • Indication: Analyte Biochemistry
  • Authors: Fenske WK, Schnyder I, Koch G, Walti C, Pfister M, Kopp P, Fassnacht M, Strauss K and Christ-Crain M
  • Source: J Clin Endocrinol Metab 2018;103 (2),Feb 1: 505-513
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