Studies about Copeptin

Low-Osmolar Diet and Adjusted Water Intake for Vasopressin Reduction in Autosomal Dominant Polycystic Kidney Disease: A Pilot Randomized Controlled Trial

We developed a stepwise dietary intervention that led to a significant reduction in vasopressin secretion in patients with ADPKD. Furthermore, this intervention led to a reduction in water required for vasopressin reduction. >

Additional Info

  • Indication: Nephrology
  • Authors: Amro OW, Paulus JK, Noubary F and Perrone RD
  • Source: Am J Kidney Dis 2016;68 (6),Dec: 882-891.

Copeptin in the diagnosis of vasopressin-dependent disorders of fluid homeostasis

Quantification of AVP can be difficult, but copeptin is stable in plasma and can be easily measured with a sandwich immunoassay. For this reason, copeptin has emerged as a promising marker for the diagnosis of AVP-dependent fluid disorders. >

Additional Info

  • Indication: Electrolyte Disorders
  • Authors: Mirjam Christ-Crain & Wiebke Fenske
  • Source: Nature Reviews Endocrinology volume 12, pages 168–176 (2016)

Copeptin decrease from admission to discharge has favorable prognostic value for 90-day events in patients admitted with dyspnea

In patients admitted for acute dyspnea, admission, discharge and Δ copeptin variations have significant prognostic value from subsequent 90-day death and rehospitalization. >

Additional Info

  • Indication: Emergency Medicine
  • Authors: Vetrone F, Santarelli S, Russo V, Lalle I, De Berardinis B, Magrini L, Di Stasio E, Salerno G, Cardelli P, Piccoli A, Codognotto M, Mion MM, Plebani M, Vettore G, Castello LM, Avanzi GC and Di Somma S
  • Source: Clin Chem Lab Med 2014;52 (10),Oct: 1457-64.

Emerging biomarkers for acute heart conditions

Galectin-3 is an active biomarker found in inflammatory and fibrotic processes, and is a marker of mortality. ST2 is released by stressed cardiac myocytes and also predicts mortality in heart failure and myocardial infarction. Copeptin is a stable arginine vasopressin precursor associated with increased risk of heart failure. It may also be useful to exclude acute myocardial infarction. >

Additional Info

  • Indication: Cardiology
  • Authors: Vasile VC and Jaffe AS
  • Source: Curr Opin Cardiol 2014;29 (4),Jul: 312-8.

Copeptin (CTproAVP), a new tool for understanding the role of vasopressin in pathophysiology

Activation of the AVP system stimulates CTproAVP secretion into the circulation from the posterior pituitary gland in equimolar amounts with AVP. Therefore CTproAVP directly reflects AVP concentration and can be used as a surrogate biomarker of AVP secretion. In many studies CTproAVP represents AVP levels and its behavior represents changes in plasma osmolality, stress and various disease states, and shows some of the various physiologic and pathophysiologic conditions associated with increased or decreased AVP. >

Additional Info

  • Indication: Review
  • Authors: Bolignano D, Cabassi A, Fiaccadori E, Ghigo E, Pasquali R, Peracino A, Peri A, Plebani M, Santoro A, Settanni F and Zoccali C
  • Source: Clin Chem Lab Med 2014;52 (10),Oct: 1447-56.
  • Access: Open Access
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