Polyuria-polydipsia Syndrome

Improved differential diagnosis

The challenge in the diagnosis of the polyuria-polydipsia syndrome is differentiating between cases of primary polydipsia and diabetes insipidus.

The diagnostic method of choice would be direct vasopressin determination, but the molecular characteristics of vasopressin make such measurement very complex and error-prone, hence unreliable. Consequently, “direct vasopressin testing” has not been established as a diagnostic routine.

Now, a single Copeptin measurement can immediately distinguish central diabetes insipidus from nephrogenic diabetes insipidus.

Thus Copeptin measurement reduces the burden of the water deprivation test for the majority of patients and improves patient management within the clinic. Ref-1

Smart Copeptin testing

  • Reliable results
  • Reduced costs (fewer measurements, less personnel and time)
  • Simplified lab workflow
  • Optimized patient management



References Polyuria-polydipsia syndrome

Ref-1: Timper K, Fenske W, et al. Diagnostic Accuracy of Copeptin in the Differential Diagnosis of the Polyuria-polydipsia Syndrome: A Prospective Multicenter Study. J Clin Endocrinol Metab, June 2015, 100(6):2268–22

thermo scientific applied biosystems invitrogen fisher scientific unity lab service